MSC-sEV treatment polarizes pro-fibrotic M2 macrophages without exacerbating liver fibrosis in NASH

• Main Authors: Zhang, Bin, Zhang, Biyan, Lai, Ruenn Chai, Sim, Wei Kian, Lam, Kong Peng, Lim, Sai Kiang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Immunomodulation; M2 Macrophage
• Online Access: https://hdl.handle.net/10356/169574
• Institution: Nanyang Technological University

Mesenchymal stem/stromal cell small extracellular vesicles (MSC-sEVs) have shown promise in treating a wide range of animal models of various human diseases, which has led to their consideration for clinical translation. However, the possibility of contraindication for MSC-sEV use is an important co...