Unravelling the role of obesity and lipids during tumor progression

• Main Authors: Zhao, Junzhe, Lee, Keene, Toh, Han Chong, Lam, Kong Peng, Neo, Shi Yong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Hepatocellular Carcinoma; Adipocytes
• Online Access: https://hdl.handle.net/10356/169598
• Institution: Nanyang Technological University

The dysregulation of the biochemical pathways in cancer promotes oncogenic transformations and metastatic potential. Recent studies have shed light on how obesity and altered lipid metabolism could be the driving force for tumor progression. Here, in this review, we focus on liver cancer and discuss how obesity and lipid-driven metabolic reprogramming affect tumor, immune, and stroma cells in the tumor microenvironment and, in turn, how alterations in these cells synergize to influence and contribute to tumor growth and dissemination. With increasing evidence on how obesity exacerbates inflammation and immune tolerance, we also touch upon the impact of obesity and altered lipid metabolism on tumor immune escape.