Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

• Main Authors: Rashid, Rafi, Nair, Zeus J., Chia, Dominic Ming Hao, Chong, Kelvin Kian Long, Cazenave Gassiot, Amaury, Morley, Stewart A., Allen, Doug K., Chen, Swaine L., Chng, Shu-Sin, Wenk, Markus R., Kline, Kimberly A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Multiple Peptide Resistance Factor; Cationic Antimicrobial Peptides
• Online Access: https://hdl.handle.net/10356/169626
• Institution: Nanyang Technological University

The bacterial cell membrane is an interface for cell envelope synthesis, protein secretion, virulence factor assembly, and a target for host cationic antimicrobial peptides (CAMPs). To resist CAMP killing, several Gram-positive pathogens encode the multiple peptide resistance factor (MprF) enzyme th...