Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

• Main Authors: Rashid, Rafi, Nair, Zeus J., Chia, Dominic Ming Hao, Chong, Kelvin Kian Long, Cazenave Gassiot, Amaury, Morley, Stewart A., Allen, Doug K., Chen, Swaine L., Chng, Shu-Sin, Wenk, Markus R., Kline, Kimberly A.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Biological sciences; Multiple Peptide Resistance Factor; Cationic Antimicrobial Peptides
• 在線閱讀: https://hdl.handle.net/10356/169626

The bacterial cell membrane is an interface for cell envelope synthesis, protein secretion, virulence factor assembly, and a target for host cationic antimicrobial peptides (CAMPs). To resist CAMP killing, several Gram-positive pathogens encode the multiple peptide resistance factor (MprF) enzyme th...