Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool

Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. Methods: One hundred fifty-seven participants were...

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Main Authors: Tran, Bach Xuan, Nguyen, Tham Thi, Boyer, Laurent, Fond, Guillaume, Auquier, Pascal, Nguyen, Hao Si Anh, Tran, Ha Thi Nhi, Nguyen, Hung Manh, Choi, Jongkwan, Le, Huong Thi, Latkin, Carl A., Nathan, Kalpana Isabel, Husain, Syeda F., McIntyre, Roger S., Ho, Cyrus S. H., Zhang, Melvyn, Ho, Roger C. M.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/169709
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-169709
record_format dspace
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Spectrometry
Cortical Hemodynamic Response
spellingShingle Science::Medicine
Spectrometry
Cortical Hemodynamic Response
Tran, Bach Xuan
Nguyen, Tham Thi
Boyer, Laurent
Fond, Guillaume
Auquier, Pascal
Nguyen, Hao Si Anh
Tran, Ha Thi Nhi
Nguyen, Hung Manh
Choi, Jongkwan
Le, Huong Thi
Latkin, Carl A.
Nathan, Kalpana Isabel
Husain, Syeda F.
McIntyre, Roger S.
Ho, Cyrus S. H.
Zhang, Melvyn
Ho, Roger C. M.
Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
description Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. Methods: One hundred fifty-seven participants were divided into schizophrenia (n = 110) and healthy controls group (n = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO2) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area. Results: People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731–0.872). The Youden’s index reached a peak (0.57) at the optimal cut-point value (HbO2 cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%. Discussion: Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Tran, Bach Xuan
Nguyen, Tham Thi
Boyer, Laurent
Fond, Guillaume
Auquier, Pascal
Nguyen, Hao Si Anh
Tran, Ha Thi Nhi
Nguyen, Hung Manh
Choi, Jongkwan
Le, Huong Thi
Latkin, Carl A.
Nathan, Kalpana Isabel
Husain, Syeda F.
McIntyre, Roger S.
Ho, Cyrus S. H.
Zhang, Melvyn
Ho, Roger C. M.
format Article
author Tran, Bach Xuan
Nguyen, Tham Thi
Boyer, Laurent
Fond, Guillaume
Auquier, Pascal
Nguyen, Hao Si Anh
Tran, Ha Thi Nhi
Nguyen, Hung Manh
Choi, Jongkwan
Le, Huong Thi
Latkin, Carl A.
Nathan, Kalpana Isabel
Husain, Syeda F.
McIntyre, Roger S.
Ho, Cyrus S. H.
Zhang, Melvyn
Ho, Roger C. M.
author_sort Tran, Bach Xuan
title Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
title_short Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
title_full Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
title_fullStr Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
title_full_unstemmed Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
title_sort differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fnirs) as an adjunct diagnostic tool
publishDate 2023
url https://hdl.handle.net/10356/169709
_version_ 1779156752776822784
spelling sg-ntu-dr.10356-1697092023-08-06T15:38:11Z Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool Tran, Bach Xuan Nguyen, Tham Thi Boyer, Laurent Fond, Guillaume Auquier, Pascal Nguyen, Hao Si Anh Tran, Ha Thi Nhi Nguyen, Hung Manh Choi, Jongkwan Le, Huong Thi Latkin, Carl A. Nathan, Kalpana Isabel Husain, Syeda F. McIntyre, Roger S. Ho, Cyrus S. H. Zhang, Melvyn Ho, Roger C. M. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Spectrometry Cortical Hemodynamic Response Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. Methods: One hundred fifty-seven participants were divided into schizophrenia (n = 110) and healthy controls group (n = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO2) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area. Results: People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731–0.872). The Youden’s index reached a peak (0.57) at the optimal cut-point value (HbO2 cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%. Discussion: Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries. Published version This study received funding from the Gia Lam Urban Development and Investment Company Limited, Vingroup, Vingroup Innovation Foundation (VINIF) (Grant No. VINIF.2019.DA14), NUS Department of Psychological Medicine (R177-000-100-001/R-177-000-003-001), and NUS iHeathtech Other Operating Expenses (R-722-000-004-731). 2023-08-01T00:39:00Z 2023-08-01T00:39:00Z 2023 Journal Article Tran, B. X., Nguyen, T. T., Boyer, L., Fond, G., Auquier, P., Nguyen, H. S. A., Tran, H. T. N., Nguyen, H. M., Choi, J., Le, H. T., Latkin, C. A., Nathan, K. I., Husain, S. F., McIntyre, R. S., Ho, C. S. H., Zhang, M. & Ho, R. C. M. (2023). Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool. Frontiers in Psychiatry, 14, 1061284-. https://dx.doi.org/10.3389/fpsyt.2023.1061284 1664-0640 https://hdl.handle.net/10356/169709 10.3389/fpsyt.2023.1061284 36778640 2-s2.0-85147779547 14 1061284 en VINIF.2019.DA14 R177-000-100-001 R-177-000-003-001 R-722-000-004-731 Frontiers in Psychiatry © 2023 Tran, Nguyen, Boyer, Fond, Auquier, Nguyen, Tran, Nguyen, Choi, Le, Latkin, Nathan, Husain, McIntyre, Ho, Zhang and Ho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf