The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration

• Main Authors: Wong, Darren Chen Pei, Pan, Catherine Qiurong, Er, Shi Yin, Thivakar, T., Tan, Rachel Zi Yi, Seah, Sock Hong, Chua, Pei Jou, Jiang, Tingting, Chew, Ti Weng, Chaudhuri, Parthiv Kant, Mukherjee, Somsubhro, Salim, Agus, Aye, Thike Aye, Koh, Cheng Gee, Lim, Chwee Teck, Tan, Puay Hoon, Bay, Boon Huat, Ridley, Anne J., Low, Boon Chuan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Rho Factor; Scaffold Protein
• Online Access: https://hdl.handle.net/10356/169717
• Institution: Nanyang Technological University

Rho GTPases regulate cell morphogenesis and motility under the tight control of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). However, the underlying mechanism(s) that coordinate their spatiotemporal activities, whether separately or together, remain unclear. We s...