The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis
Study Design: A systematic review. Purpose: This study aimed to evaluate the prevalence of coexisting lumbar spondylosis (LS) and knee osteoarthritis (KOA), which has clinical implications on the screening, diagnosis, and management of orthopedic patients. Overview of Literature: Due to current gl...
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sg-ntu-dr.10356-1697192023-08-06T15:38:13Z The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis Betzler, Brjan Kaiji Ng, Faye Yu Ci Huang, Yilun Hamid Rahmatullah Bin Abd Razak Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Knee Osteoarthritis Spondylosis Study Design: A systematic review. Purpose: This study aimed to evaluate the prevalence of coexisting lumbar spondylosis (LS) and knee osteoarthritis (KOA), which has clinical implications on the screening, diagnosis, and management of orthopedic patients. Overview of Literature: Due to current global health trends, the number of affected patients is expected to increase substantially. However, no prior systematic reviews have discussed this topic. Methods: A systematic literature search was conducted in June 2021 in the PubMed, Embase, Scopus, CINAHL, and Cochrane CENTRAL databases. Clinical and epidemiological studies that reported quantitative data on the prevalence of coexisting LS and KOA were included. Studies which reported data on only LS or KOA alone were excluded. Odds ratios (ORs) and 95% confidence intervals (CI) for LS or KOA were retrieved or calculated for meta-analysis. Fixed-effects and random-effects models were used, and statistical significance was considered when p<0.05. Heterogeneity was evaluated using Cochran’s Q test and the I2 statistic. Risk of bias was assessed using the MINORs (methodological index for nonrandomized studies) criteria. Results: This review included nine studies (5,758 patients). Four studies (4,164 patients) defined KOA and LS by a Kellgren-Lawrence (KL) grade of ≥2 and were included in the meta-analysis. Two other studies defined KOA and LS by a joint space narrowing grade of ≥2. The remaining three studies reported other outcomes. The combined ORs of having KOA of KL grade ≥2 due to LS was 1.75 (95% CI, 1.22–2.50; p=0.002), while the combined OR of having LS of KL grade ≥2 due to KOA was 1.84 (95% CI, 1.23–2.77; p=0.003). Conclusions: In patients with either KOA or LS, the odds of having a concurrent knee-spine presentation are significantly increased. This may have implications for clinical decision-making and treatment strategies. Further high-level studies with larger patient populations are required to confirm these results in specific populations. Published version 2023-08-01T05:06:16Z 2023-08-01T05:06:16Z 2022 Journal Article Betzler, B. K., Ng, F. Y. C., Huang, Y. & Hamid Rahmatullah Bin Abd Razak (2022). The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis. Asian Spine Journal, 16(6), 839-847. https://dx.doi.org/10.31616/asj.2021.0405 1976-1902 https://hdl.handle.net/10356/169719 10.31616/asj.2021.0405 35421911 2-s2.0-85146743383 6 16 839 847 en Asian Spine Journal © 2022 by Korean Society of Spine Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
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Science::Medicine Knee Osteoarthritis Spondylosis Betzler, Brjan Kaiji Ng, Faye Yu Ci Huang, Yilun Hamid Rahmatullah Bin Abd Razak The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
description |
Study Design: A systematic review.
Purpose: This study aimed to evaluate the prevalence of coexisting lumbar spondylosis (LS) and knee osteoarthritis (KOA), which has clinical implications on the screening, diagnosis, and management of orthopedic patients.
Overview of Literature: Due to current global health trends, the number of affected patients is expected to increase substantially. However, no prior systematic reviews have discussed this topic.
Methods: A systematic literature search was conducted in June 2021 in the PubMed, Embase, Scopus, CINAHL, and Cochrane CENTRAL databases. Clinical and epidemiological studies that reported quantitative data on the prevalence of coexisting LS and KOA were included. Studies which reported data on only LS or KOA alone were excluded. Odds ratios (ORs) and 95% confidence intervals (CI) for LS or KOA were retrieved or calculated for meta-analysis. Fixed-effects and random-effects models were used, and statistical significance was considered when p<0.05. Heterogeneity was evaluated using Cochran’s Q test and the I2 statistic. Risk of bias was assessed using the MINORs (methodological index for nonrandomized studies) criteria.
Results: This review included nine studies (5,758 patients). Four studies (4,164 patients) defined KOA and LS by a Kellgren-Lawrence (KL) grade of ≥2 and were included in the meta-analysis. Two other studies defined KOA and LS by a joint space narrowing grade of ≥2. The remaining three studies reported other outcomes. The combined ORs of having KOA of KL grade ≥2 due to LS was 1.75 (95% CI, 1.22–2.50; p=0.002), while the combined OR of having LS of KL grade ≥2 due to KOA was 1.84 (95% CI, 1.23–2.77; p=0.003).
Conclusions: In patients with either KOA or LS, the odds of having a concurrent knee-spine presentation are significantly increased. This may have implications for clinical decision-making and treatment strategies. Further high-level studies with larger patient populations are required to confirm these results in specific populations. |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Betzler, Brjan Kaiji Ng, Faye Yu Ci Huang, Yilun Hamid Rahmatullah Bin Abd Razak |
format |
Article |
author |
Betzler, Brjan Kaiji Ng, Faye Yu Ci Huang, Yilun Hamid Rahmatullah Bin Abd Razak |
author_sort |
Betzler, Brjan Kaiji |
title |
The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
title_short |
The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
title_full |
The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
title_fullStr |
The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
title_full_unstemmed |
The prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
title_sort |
prevalence of coexisting lumbar spondylosis and knee osteoarthritis: a systematic review and meta-analysis |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/169719 |
_version_ |
1779156415462506496 |