Investigation of the activity and modes of action of VF16QKNS, an analog of thanatin, against gram-negative bacteria

• Main Author: Chong, Carina Wei Ting
• Other Authors: Surajit Bhattacharyya
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/169750
• Institution: Nanyang Technological University

The rapid emergence of antimicrobial resistance highlights the necessary development of novel antimicrobial compounds. Thanatin, a 21-residue long antimicrobial peptide, exhibits a broad spectrum of antimicrobial activity. In gram-negative bacteria, native thanatin’s dual mode of action comprises ou...