Zebrafish pigment cells develop directly from persistent highly multipotent progenitors

• Main Authors: Subkhankulova, Tatiana, Sosa, Karen Camargo, Uroshlev, Leonid A., Nikaido, Masataka, Shriever, Noah, Kasianov, Artem S., Yang, Xueyan, Rodrigues, Frederico S. L. M., Carney, Tom J., Bavister, Gemma, Schwetlick, Hartmut, Dawes, Jonathan H. P., Rocco, Andrea, Makeev, Vsevolod J., Kelsh, Robert N.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Leukocyte Tyrosine Kinase; Multipotent Stem Cell
• Online Access: https://hdl.handle.net/10356/169754
• Institution: Nanyang Technological University

Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. The direct fate restriction model hypothesises that migrating cells maintain full multipotency, whilst progressive fate restriction envisages fully multipotent cells tran...