Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives

• Main Authors: Huang, Bei, Chau, Steven W. H., Liu, Yaping, Chan, Joey W. Y., Wang, Jing, Ma, Suk Ling, Zhang, Jihui, Chan, Paul K. S., Yeoh, Yun Kit, Chen, Zigui, Zhou, Li, Wong, Sunny Hei, Mok, Vincent C. T., To, Ka Fai, Lai, Hei Ming, Ng, Simon, Trenkwalder, Claudia, Chan, Francis K. L., Wing, Yun Kwok
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Antidepressant Agent; Anxiety Disorder
• Online Access: https://hdl.handle.net/10356/169763
• Institution: Nanyang Technological University

The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which co...