A pair of siblings with Wolfram Syndrome: a review of the literature and treatment options

• Main Authors: Png, Doanna, Yeoh, Ester, Tan, Clara, Lim, Su Chi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Wolfram Syndrome; Diabetes Mellitus
• Online Access: https://hdl.handle.net/10356/169815
• Institution: Nanyang Technological University

Wolfram syndrome (WS) is a rare genetic disorder typically characterized by juvenile onset diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, and neurodegeneration. There would be a high index of clinical suspicion for WS when clinical manifestations of type 1 diabetes and optic atr...