Case report: olaparib use in metastatic lung adenocarcinoma with BRCA2 pathogenic variant

• Main Authors: Soon, Jonathan Jian Hao, Chan, Sock Hoai, Tan, Daniel Shao Weng, Ngeow, Joanne, Chiang, Jianbang
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Chronic Lung Disease; Lung Adenocarcinoma
• Online Access: https://hdl.handle.net/10356/169833
• Institution: Nanyang Technological University

Poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in malignancies associated with germline BRCA1 or BRCA2 pathogenic variants, such as breast, ovarian, prostate, and pancreatic cancer. In malignancies not associated with germline BRCA1 or BRCA2 pathogenic variants, the therapeutic re...