Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease

• Main Authors: Fairley, Lauren H., Lai, Kei Onn, Wong, Jia Hui, Chong, Wei Jing, Vincent, Anselm Salvatore, D'Agostino, Giuseppe, Wu, Xiaoting, Naik, Roshan R., Jayaraman, Anusha, Langley, Sarah Raye, Ruedl, Christiane, Barron, Anna M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Microglia; Alzheimer's disease
• Online Access: https://hdl.handle.net/10356/169856
• Institution: Nanyang Technological University

Microglial phagocytosis is an energetically demanding process that plays a critical role in the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence indicates that a switch in energy production from mitochondrial respiration to glycolysis disrupts this important prot...