Reliable quantification of citrate isomers and isobars with direct-infusion tandem mass spectrometry

• Main Authors: Hu, Qingyu, Sun, Yuting, Mu, Xiyan, Wang, Yulan, Tang, Huiru
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Medicine; Citrate Isomers; Collision-induced Dissociation
• 在線閱讀: https://hdl.handle.net/10356/169947
• 機構: Nanyang Technological University

Direct-infusion tandem mass spectrometry (DI-MS/MS) is an excellent tool for large cohort high-throughput quantitative metabolomics, MS imaging and single cell studies but incapable of discriminating isomers/isobars with similar MS spectral features. With experimental and density-functional theory (...