Reliable quantification of citrate isomers and isobars with direct-infusion tandem mass spectrometry

• المؤلفون الرئيسيون: Hu, Qingyu, Sun, Yuting, Mu, Xiyan, Wang, Yulan, Tang, Huiru
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Citrate Isomers; Collision-induced Dissociation
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169947

Direct-infusion tandem mass spectrometry (DI-MS/MS) is an excellent tool for large cohort high-throughput quantitative metabolomics, MS imaging and single cell studies but incapable of discriminating isomers/isobars with similar MS spectral features. With experimental and density-functional theory (...