TWEAK/Fn14 distinctly remodels the transcriptomic and epigenetic landscape in triple negative breast cancer to drive its progression

• Main Author: Sim, Nicholas Yang-U
• Other Authors: Li Yinghui
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences::Genetics; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/169950
• Institution: Nanyang Technological University

Breast cancer is the most prevalent malignancy in women and one of the leading causes of cancer-related deaths globally. Of which, roughly 20% of cases are Triple Negative Breast Cancers (TNBC) which are highly aggressive and lack hormone receptors, rendering standard systemic therapy ineffective. C...