Catalyst-free reactions under biocompatible conditions
Catalyst-free biocompatible reactions are a class of green chemical processes that are also applicable to the field of chemical biology. In this account, we detail our journey in this exciting area of research since 2000. Various types of catalyst-free biocompatible reactions, such as the Mukaiyama...
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sg-ntu-dr.10356-1701302023-08-29T03:04:47Z Catalyst-free reactions under biocompatible conditions Ren, Mi Lu, Ming-Zhu Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Catalyst-Free Reaction Biocompatibility Catalyst-free biocompatible reactions are a class of green chemical processes that are also applicable to the field of chemical biology. In this account, we detail our journey in this exciting area of research since 2000. Various types of catalyst-free biocompatible reactions, such as the Mukaiyama aldol reactions and thiol-specific click reactions, and their applications to the functionalization of proteins are described. These reactions work well without destroying the three-dimensional structures of the proteins. Other reactions, including the C- SO2 and C-N bond-forming reactions, are also discussed. These reactions work in a truly green manner in which the use of organic solvents can be totally avoided. This toolbox of green chemical processes will certainly facilitate the work of researchers in the pharmaceutical industries. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University We gratefully acknowledge generous financial support from the National Natural Science Foundation of China (no. 22101095) and the Innovation and Entrepreneurship Talents Plan of Jiangsu Province (M.-Z.L.). We also gratefully acknowledge the financial support from Distinguished University Professor Grant (Nanyang Technological University), AcRF Tier 1 grants from the Ministry of Education of Singapore (RG11/20 and RT14/20), and the Agency for Science, Technology and Research (A*STAR) under its MTC Individual Research Grants (M21K2c0114). 2023-08-29T03:04:46Z 2023-08-29T03:04:46Z 2022 Journal Article Ren, M., Lu, M. & Loh, T. (2022). Catalyst-free reactions under biocompatible conditions. Synlett, 34(12), 1309-1316. https://dx.doi.org/10.1055/a-1994-3327 0936-5214 https://hdl.handle.net/10356/170130 10.1055/a-1994-3327 2-s2.0-85144900561 12 34 1309 1316 en RG11/20 RT14/20 M21K2c0114 Synlett © 2023 Thieme. All rights reserved. |
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Science::Chemistry Catalyst-Free Reaction Biocompatibility Ren, Mi Lu, Ming-Zhu Loh, Teck-Peng Catalyst-free reactions under biocompatible conditions |
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Catalyst-free biocompatible reactions are a class of green chemical processes that are also applicable to the field of chemical biology. In this account, we detail our journey in this exciting area of research since 2000. Various types of catalyst-free biocompatible reactions, such as the Mukaiyama aldol reactions and thiol-specific click reactions, and their applications to the functionalization of proteins are described. These reactions work well without destroying the three-dimensional structures of the proteins. Other reactions, including the C- SO2 and C-N bond-forming reactions, are also discussed. These reactions work in a truly green manner in which the use of organic solvents can be totally avoided. This toolbox of green chemical processes will certainly facilitate the work of researchers in the pharmaceutical industries. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Ren, Mi Lu, Ming-Zhu Loh, Teck-Peng |
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Article |
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Ren, Mi Lu, Ming-Zhu Loh, Teck-Peng |
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Ren, Mi |
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Catalyst-free reactions under biocompatible conditions |
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Catalyst-free reactions under biocompatible conditions |
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Catalyst-free reactions under biocompatible conditions |
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Catalyst-free reactions under biocompatible conditions |
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Catalyst-free reactions under biocompatible conditions |
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catalyst-free reactions under biocompatible conditions |
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2023 |
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https://hdl.handle.net/10356/170130 |
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