Power-free contact lens for glucose sensing
Recent advances in wearable devices have enabled noninvasive monitoring for healthcare applications. Smart contact lenses have gained substantial attention for medical diagnosis through the analysis of vital signs in tear fluids. However, previous studies have mostly focused on designs embedded with...
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sg-ntu-dr.10356-1702282023-11-24T15:41:07Z Power-free contact lens for glucose sensing Li, Zongkang Yun, Jeonghun Li, Xiaoya Kim, Moobum Li, Jia Lee, Donghoon Wu, Angyin Lee, Seok Woo School of Electrical and Electronic Engineering Rolls-Royce@NTU Corporate Lab Engineering::Bioengineering Color Change Glucose Sensing Recent advances in wearable devices have enabled noninvasive monitoring for healthcare applications. Smart contact lenses have gained substantial attention for medical diagnosis through the analysis of vital signs in tear fluids. However, previous studies have mostly focused on designs embedded with electronic devices or antennas for wireless transmission, which are power-intensive and require external receivers around the ocular system. Here, the study reports a power-free smart contact lens for noninvasive glucose sensing according to the color changes of multiple electrochromic electrodes to achieve direct data transmission without the external wireless system. The device detects various glucose concentrations, from the ordinary range (0.16–0.5 mm) to abnormally high concentrations (0.9 mm). The multi-electrode design exhibits acceptable accuracy, with a correlation coefficient r = 0.99543 to the controlled sample and allowed low-glucose detections with concentrations down to 0.05 mm. The device shows good reproducibility, with standard deviations of determined glucose levels of 0.0462 and 0.025 for four continuous cycles and for an interval of several days, respectively. It is believed that the reported smart contact lens has the potential for daily health monitoring by ordinary users without a power supply and external devices. Its simple electronics-free structure will allow for immediate application to the market with cost-effective manufacturing. National Research Foundation (NRF) Submitted/Accepted version S.W.L. acknowledges the support by the National Research Foundation, Prime Minister’s Office, Singapore under its NRF-ANR Joint Pro-gramme (NRF2019-NRF-ANR052 KineHarvest). 2023-09-04T02:19:14Z 2023-09-04T02:19:14Z 2023 Journal Article Li, Z., Yun, J., Li, X., Kim, M., Li, J., Lee, D., Wu, A. & Lee, S. W. (2023). Power-free contact lens for glucose sensing. Advanced Functional Materials, 33(42), 2304647-. https://dx.doi.org/10.1002/adfm.202304647 1616-301X https://hdl.handle.net/10356/170228 10.1002/adfm.202304647 2-s2.0-85162214530 42 33 2304647 en NRF2019-NRF-ANR052 KineHarvest Advanced Functional Materials © 2023 Wiley-VCH GmbH. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1002/adfm.202304647. application/pdf |
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Engineering::Bioengineering Color Change Glucose Sensing Li, Zongkang Yun, Jeonghun Li, Xiaoya Kim, Moobum Li, Jia Lee, Donghoon Wu, Angyin Lee, Seok Woo Power-free contact lens for glucose sensing |
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Recent advances in wearable devices have enabled noninvasive monitoring for healthcare applications. Smart contact lenses have gained substantial attention for medical diagnosis through the analysis of vital signs in tear fluids. However, previous studies have mostly focused on designs embedded with electronic devices or antennas for wireless transmission, which are power-intensive and require external receivers around the ocular system. Here, the study reports a power-free smart contact lens for noninvasive glucose sensing according to the color changes of multiple electrochromic electrodes to achieve direct data transmission without the external wireless system. The device detects various glucose concentrations, from the ordinary range (0.16–0.5 mm) to abnormally high concentrations (0.9 mm). The multi-electrode design exhibits acceptable accuracy, with a correlation coefficient r = 0.99543 to the controlled sample and allowed low-glucose detections with concentrations down to 0.05 mm. The device shows good reproducibility, with standard deviations of determined glucose levels of 0.0462 and 0.025 for four continuous cycles and for an interval of several days, respectively. It is believed that the reported smart contact lens has the potential for daily health monitoring by ordinary users without a power supply and external devices. Its simple electronics-free structure will allow for immediate application to the market with cost-effective manufacturing. |
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School of Electrical and Electronic Engineering |
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School of Electrical and Electronic Engineering Li, Zongkang Yun, Jeonghun Li, Xiaoya Kim, Moobum Li, Jia Lee, Donghoon Wu, Angyin Lee, Seok Woo |
format |
Article |
author |
Li, Zongkang Yun, Jeonghun Li, Xiaoya Kim, Moobum Li, Jia Lee, Donghoon Wu, Angyin Lee, Seok Woo |
author_sort |
Li, Zongkang |
title |
Power-free contact lens for glucose sensing |
title_short |
Power-free contact lens for glucose sensing |
title_full |
Power-free contact lens for glucose sensing |
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Power-free contact lens for glucose sensing |
title_full_unstemmed |
Power-free contact lens for glucose sensing |
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power-free contact lens for glucose sensing |
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2023 |
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https://hdl.handle.net/10356/170228 |
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1783955549604282368 |