Reactive oxygen species-scavenging nanosystems in the treatment of diabetic wounds

• Main Authors: Xiong, Yuan, Chu, Xiangyu, Yu, Tao, Knoedler, Samuel, Schroeter, Andreas, Lu, Li, Zha, Kangkang, Lin, Ze, Jiang, Dongsheng, Rinkevich, Yuval, Panayi, Adriana C., Mi, Bobin, Liu, Guohui, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Biomedical Nanosystems; Diabetic Wounds
• Online Access: https://hdl.handle.net/10356/170258
• Institution: Nanyang Technological University

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, and oxidative damage to the microenvironment. Given their complex nature, diabetic wounds remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown to trigger hyperinflammation and excessive cellular apoptosis, play a pivotal role in the pathogenesis of diabetic wounds. ROS-scavenging nanosystems have recently emerged as smart and multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory and pro-angiogenic ability of ROS-scavenging treatments predestines these nanosystems as promising options for the treatment of diabetic wounds. Yet, in this context, the therapeutic applicability and efficacy of ROS-scavenging nanosystems remain to be elucidated. Herein, the role of ROS in diabetic wounds is deciphered, and the properties and strengths of nanosystems with ROS-scavenging capacity for the treatment of diabetic wounds are summarized. In addition, the current challenges of such nanosystems and their potential future directions are discussed through a clinical-translational lens.