Reversible-hydrogen-transfer-mediated anomerization of azaheterocyclyl 2-deoxy-C-glycosides and mechanistic studies

• Main Authors: Mu, Qiu-Qi, Guo, Aoxin, Cai, Xin, Qin, Yang-Yang, Fang, Xin-Yu, Peng, Li-Cong, Feng, Chao, Xu, Li-Wen, Xiao, Xiong, Liu, Xue-Wei
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Reversible-Hydrogen-Transfer; C-Glycoside Anomerization
• Online Access: https://hdl.handle.net/10356/170264
• Institution: Nanyang Technological University

Mutarotation of O-glycans and O-glycosides has long been well-established and exploited in the stereocontrolled chemical synthesis of O-glycosides, while few examples of C-glycoside anomerization are known to date. During the development of a simple iridium catalyst-promoted α-stereoselective C-glyc...