Biomolecular condensates tunes immune signaling at the Host-Pathogen interface
Membraneless organelles participate in diverse spatiotemporal regulation of cellular signal transduction by recruiting necessary signaling factors. During host-pathogen interactions, the plasma membrane (PM) at the interface between the plant and microbes serves as a central platform for forming mul...
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sg-ntu-dr.10356-1702862023-09-06T01:43:39Z Biomolecular condensates tunes immune signaling at the Host-Pathogen interface Miao Yansong Guo, Xiangfu Zhu, Kexin Zhao, Wenting School of Biological Sciences School of Chemistry, Chemical Engineering and Biotechnology Institute for Digital Molecular Analytics and Science Science::Biological sciences Antigen Antibody Complex Biomolecular Condensate Membraneless organelles participate in diverse spatiotemporal regulation of cellular signal transduction by recruiting necessary signaling factors. During host-pathogen interactions, the plasma membrane (PM) at the interface between the plant and microbes serves as a central platform for forming multicomponent immune signaling hubs. The macromolecular condensation of the immune complex and regulators is important in regulating immune signaling outputs regarding strength, timing, and crosstalk between signaling pathways. This review discusses mechanisms that regulate specific and crosstalk of plant immune signal transduction pathways through macromolecular assembly and condensation. Ministry of Education (MOE) Nanyang Technological University National Research Foundation (NRF) This work was funded by the Singapore MOE Tier 2 ( MOE-T2EP30121-0015 and MOE-T2EP30122-0021 to Y.M.), National Research Foundation Singapore under its Open Fund - Individual Research Grant ( MOH-000955 to Y.M.), MOE Tier 3 ( MOE2019-T3-1-012 to Y.M.), and the Human Frontier Science Program Foundation ( RGY0088/2021 to W.Z.), and the Start-up Grant from Nanyang Technological University to W.Z.). 2023-09-06T01:43:38Z 2023-09-06T01:43:38Z 2023 Journal Article Miao Yansong, Guo, X., Zhu, K. & Zhao, W. (2023). Biomolecular condensates tunes immune signaling at the Host-Pathogen interface. Current Opinion in Plant Biology, 74, 102374-. https://dx.doi.org/10.1016/j.pbi.2023.102374 1369-5266 https://hdl.handle.net/10356/170286 10.1016/j.pbi.2023.102374 37148673 2-s2.0-85154620075 74 102374 en MOE-T2EP30121-0015 MOE-T2EP30122-0021 MOH-000955 MOE2019-T3-1-012 Current Opinion in Plant Biology © 2023 Elsevier Ltd. All rights reserved. |
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Science::Biological sciences Antigen Antibody Complex Biomolecular Condensate |
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Science::Biological sciences Antigen Antibody Complex Biomolecular Condensate Miao Yansong Guo, Xiangfu Zhu, Kexin Zhao, Wenting Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| description |
Membraneless organelles participate in diverse spatiotemporal regulation of cellular signal transduction by recruiting necessary signaling factors. During host-pathogen interactions, the plasma membrane (PM) at the interface between the plant and microbes serves as a central platform for forming multicomponent immune signaling hubs. The macromolecular condensation of the immune complex and regulators is important in regulating immune signaling outputs regarding strength, timing, and crosstalk between signaling pathways. This review discusses mechanisms that regulate specific and crosstalk of plant immune signal transduction pathways through macromolecular assembly and condensation. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Miao Yansong Guo, Xiangfu Zhu, Kexin Zhao, Wenting |
| format |
Article |
| author |
Miao Yansong Guo, Xiangfu Zhu, Kexin Zhao, Wenting |
| author_sort |
Miao Yansong |
| title |
Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| title_short |
Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| title_full |
Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| title_fullStr |
Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| title_full_unstemmed |
Biomolecular condensates tunes immune signaling at the Host-Pathogen interface |
| title_sort |
biomolecular condensates tunes immune signaling at the host-pathogen interface |
| publishDate |
2023 |
| url |
https://hdl.handle.net/10356/170286 |
| _version_ |
1779156575108202496 |