Missing-linker-confined single-atomic Pt nanozymes for enzymatic theranostics of tumor

Missing-linker-confined single-atomic Pt nanozymes for enzymatic theranostics of tumor

Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single-atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile "missing-linker-confined coordination" stra...

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Bibliographic Details
Main Authors: Wang, Dongdong, Zhang, Lei, Wang, Changlai, Cheng, Zhiyu, Zheng, Wei, Xu, Pengping, Chen, Qianwang, Zhao, Yanli
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Cancer Therapy
Missing Linker
Online Access:https://hdl.handle.net/10356/170302
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Institution: Nanyang Technological University
Language: English
Description
Summary:Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single-atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile "missing-linker-confined coordination" strategy to fabricate two self-assembled nanozymes, i.e., conventional nanozyme (NE) and single-atomic nanozyme (SAE), which respectively consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, thus exhibiting a more efficient reactive oxygen species generation and high tumor inhibition rate.

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