Detachable MOF-based core/shell nanoreactor for cancer dual-starvation therapy with reversing glucose and glutamine metabolisms

• Main Authors: Du, Huiping, Meng, Siyu, Geng, Meijuan, Zhao, Pan, Gong, Liyang, Zheng, Xinmin, Li, Xiang, Yuan, Zhang, Yang, Hui, Zhao, Yanli, Dai, Liangliang
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Dual-starvation Therapy; Glucose Metabolism Suppression
• Online Access: https://hdl.handle.net/10356/170329
• Institution: Nanyang Technological University

Tumor-dependent glucose and glutamine metabolisms are essential for maintaining survival, while the accordingly metabolic suppressive therapy is limited by the compensatory metabolism and inefficient delivery efficiency. Herein, a functional metal-organic framework (MOF)-based nanosystem composed of...