Impact of variant reclassification in cancer predisposition genes on clinical care

• المؤلفون الرئيسيون: Chiang, Jianbang, Chia, Tze Hao, Yuen, Jeanette, Shaw, Tarryn, Li, Shao-Tzu, Nur Diana Binte Ishak, Chew, Ee Ling, Chong, Siao Ting, Chan, Sock Hoai, Ngeow, Joanne
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Cancer Genetics; Retrospective Study
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/170423

PURPOSE: Genetic testing has clinical utility in the management of patients with hereditary cancer syndromes. However, the increased likelihood of encountering a variant of uncertain significance in individuals of non- European descent such as Asians may be challenging to both clinicians and patient...