Kinetic and dynamic kinetic resolution of racemic tertiary bromides by pentanidium‐catalyzed phase‐transfer azidation

• Main Authors: Ren, Jingyun, Ban, Xu, Zhang, Xin, Tan, Siu Min, Lee, Richmond, Tan, Choon-Hong
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Asymmetric Catalysis; Dynamic Kinetic Resolution
• Online Access: https://hdl.handle.net/10356/170451
• Institution: Nanyang Technological University

We have developed a method to afford enantiomerically enriched tertiary azides and bromides through pentanidium-catalyzed kinetic resolution (KR) of racemic tertiary bromides under base-free conditions. We found that the absence of water is crucial to attain a high selectivity factor (s). On the oth...