Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein-lipid complexes

• Main Authors: Ho, James Chin Shing, Mir, Sartaj Ahmad, Cavalera, Michele, Esmaeili, Parisa, Tran, Tuan Hiep, Yann, Zandra Chew, Tran, Thi Hien, Chaudhuri, Arunima, Bendt, Anne K., Wenk, Markus R., Svanborg, Catharina
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Acyl Chain Unsaturation; Lipidomics
• Online Access: https://hdl.handle.net/10356/170490
• Institution: Nanyang Technological University

Complexes formed by the alpha1 N-terminal peptide of alpha-lactalbumin and oleic acid (alpha1-oleate) interact with lipid bilayers. Plasma membrane perturbations trigger tumor cell death but normal differentiated cells are more resistant, and their plasma membranes are less strongly affected. This s...