Transcranial deep-tissue phototherapy for Alzheimer's disease using low-dose X-ray-activated long-afterglow scintillators

• Main Authors: Ma, Mengmeng, Wang, Jing, Jiang, Hao, Chen, Qiushui, Xiao, Yi, Yang, Huanghao, Lin, Li
• Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Materials; Scintillator; X-ray
• Online Access: https://hdl.handle.net/10356/170549
• Institution: Nanyang Technological University

Non-invasive phototherapy has been emerging as an ambitious tactic for suppression of amyloid-β (Aβ) self-assembly against Alzheimer's disease (AD). However, it remains a daunting challenge to develop efficient photosensitizers for Aβ oxygenation that are activatable in a deep brain tissue thro...