Prospective study on the clinical and economic burden of venous leg ulcers in the tropics
Objective: Venous leg ulcers (VLUs) are both chronic and recurrent. The treatment of such ulcers often require multiple outpatient visits and dressing changes. Several reports on the costs of treating such VLUs have been reported in the west. We prospectively evaluated the clinical and economic burd...
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sg-ntu-dr.10356-1705632023-09-19T06:09:57Z Prospective study on the clinical and economic burden of venous leg ulcers in the tropics Chan, Dexter Yak Seng Surendra, Naren Kumar Ng, Yi Zhen Lee, Sze-Han Yong, Enming Hong, Qiantai Goh, Cheng Cheng Lai, Tina Peiting Tan, Audrey Hui Min Law, Chelsea Chiew Chie Liang, Shanying Car, Josip Lo, Joseph Zhiwen Lee Kong Chian School of Medicine (LKCMedicine) Centre for Population Health Sciences Science::Medicine Chronic Venous Insufficiency Quality of Life Objective: Venous leg ulcers (VLUs) are both chronic and recurrent. The treatment of such ulcers often require multiple outpatient visits and dressing changes. Several reports on the costs of treating such VLUs have been reported in the west. We prospectively evaluated the clinical and economic burden of VLUs in a population of Asian patients in the tropics. Methods: Patients from a prospective two-center study conducted at two tertiary hospitals in Singapore, as a part of the Wound Care Innovation in the Tropics program, between August 2018 and September 2021 were recruited. The patients were followed up for 12 weeks (visit 1 to visit 12), until index ulcer healing, death, or lost to follow-up (whichever came first). These patients were then followed up 12 weeks later to determine the longer term outcome of the wound (healed, recurrence, remained unhealed). The itemized costs derived from the medical service were retrieved from the relevant departments of the study sites. The patients' health-related quality of life was assessed at baseline and the last visit of the 12-week follow-up period (or until index ulcer healing), using the official Singapore version of the EuroQol five-dimension-5L questionnaire, which also includes a visual analog scale (EQ-VAS). Results: A total of 116 patients were enrolled; 63% were men, and the mean patient age was 64.7 years. Of the 116 patients, 85 (73%) had a healed ulcer at 24 weeks (mean duration to ulcer healing, 49 days), and 11 (12.9%) had experienced ulcer recurrence within the study period. Within the 6-month follow-up period, the mean direct healthcare cost per patient was USD$1998. The patients with healed ulcers had significantly lower costs per patient compared with those with unhealed ulcers (USD$1713 vs USD$2780). Regarding health-related quality of life, 71% of the patients had a lower quality of life at baseline, which had improved at 12 weeks of follow-up, with only 58% of the patients reported to have a lower quality of life. Also, the patients with healed ulcers scored higher for both utilities (societal preference weights) and EQ-VAS at follow-up (P [removed] Agency for Science, Technology and Research (A*STAR) The present study was supported by the Industry Alignment Fund – Pre-Positioning Programme from the Agency for Science, Technology and Research (grant H18/01/a0/ZZ9). 2023-09-19T06:09:57Z 2023-09-19T06:09:57Z 2023 Journal Article Chan, D. Y. S., Surendra, N. K., Ng, Y. Z., Lee, S., Yong, E., Hong, Q., Goh, C. C., Lai, T. P., Tan, A. H. M., Law, C. C. C., Liang, S., Car, J. & Lo, J. Z. (2023). Prospective study on the clinical and economic burden of venous leg ulcers in the tropics. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 11(5), 954-963. https://dx.doi.org/10.1016/j.jvsv.2023.05.009 2213-333X https://hdl.handle.net/10356/170563 10.1016/j.jvsv.2023.05.009 37209840 2-s2.0-85161334413 5 11 954 963 en H18/01/a0/ZZ9 Journal of Vascular Surgery: Venous and Lymphatic Disorders © 2023 by the Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved. |
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Science::Medicine Chronic Venous Insufficiency Quality of Life Chan, Dexter Yak Seng Surendra, Naren Kumar Ng, Yi Zhen Lee, Sze-Han Yong, Enming Hong, Qiantai Goh, Cheng Cheng Lai, Tina Peiting Tan, Audrey Hui Min Law, Chelsea Chiew Chie Liang, Shanying Car, Josip Lo, Joseph Zhiwen Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
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Objective: Venous leg ulcers (VLUs) are both chronic and recurrent. The treatment of such ulcers often require multiple outpatient visits and dressing changes. Several reports on the costs of treating such VLUs have been reported in the west. We prospectively evaluated the clinical and economic burden of VLUs in a population of Asian patients in the tropics.
Methods: Patients from a prospective two-center study conducted at two tertiary hospitals in Singapore, as a part of the Wound Care Innovation in the Tropics program, between August 2018 and September 2021 were recruited. The patients were followed up for 12 weeks (visit 1 to visit 12), until index ulcer healing, death, or lost to follow-up (whichever came first). These patients were then followed up 12 weeks later to determine the longer term outcome of the wound (healed, recurrence, remained unhealed). The itemized costs derived from the medical service were retrieved from the relevant departments of the study sites. The patients' health-related quality of life was assessed at baseline and the last visit of the 12-week follow-up period (or until index ulcer healing), using the official Singapore version of the EuroQol five-dimension-5L questionnaire, which also includes a visual analog scale (EQ-VAS).
Results: A total of 116 patients were enrolled; 63% were men, and the mean patient age was 64.7 years. Of the 116 patients, 85 (73%) had a healed ulcer at 24 weeks (mean duration to ulcer healing, 49 days), and 11 (12.9%) had experienced ulcer recurrence within the study period. Within the 6-month follow-up period, the mean direct healthcare cost per patient was USD$1998. The patients with healed ulcers had significantly lower costs per patient compared with those with unhealed ulcers (USD$1713 vs USD$2780). Regarding health-related quality of life, 71% of the patients had a lower quality of life at baseline, which had improved at 12 weeks of follow-up, with only 58% of the patients reported to have a lower quality of life. Also, the patients with healed ulcers scored higher for both utilities (societal preference weights) and EQ-VAS at follow-up (P [removed] |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Chan, Dexter Yak Seng Surendra, Naren Kumar Ng, Yi Zhen Lee, Sze-Han Yong, Enming Hong, Qiantai Goh, Cheng Cheng Lai, Tina Peiting Tan, Audrey Hui Min Law, Chelsea Chiew Chie Liang, Shanying Car, Josip Lo, Joseph Zhiwen |
format |
Article |
author |
Chan, Dexter Yak Seng Surendra, Naren Kumar Ng, Yi Zhen Lee, Sze-Han Yong, Enming Hong, Qiantai Goh, Cheng Cheng Lai, Tina Peiting Tan, Audrey Hui Min Law, Chelsea Chiew Chie Liang, Shanying Car, Josip Lo, Joseph Zhiwen |
author_sort |
Chan, Dexter Yak Seng |
title |
Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
title_short |
Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
title_full |
Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
title_fullStr |
Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
title_full_unstemmed |
Prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
title_sort |
prospective study on the clinical and economic burden of venous leg ulcers in the tropics |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/170563 |
_version_ |
1779156459879137280 |