Design of potent and salt-insensitive antimicrobial branched peptides

• Main Authors: To, Janet, Zhang, Xiaohong, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Peptide Dendrimers; Antimicrobial Peptides; Polymeric Scaffolds; Isolysine Scaffold; Lysine Reverse Turns; Branched Peptides
• Online Access: https://hdl.handle.net/10356/170612
• Institution: Nanyang Technological University

Dendrimeric and branched peptides are polypeptides formed by diverse types of scaffolds to give them different forms. Previously, we reported a cascade-type, Lys-scaffolded antimicrobial peptide dendrimer D4R tethered with four RLYR tetrapeptides. Antimicrobial D4R is broad-spectrum, salt insensitiv...