Ginsentide-like coffeetides isolated from coffee waste are cell-penetrating and metal-binding microproteins

• Main Authors: Tam, James P., Huang, Jiayi, Loo, Shining, Li, Yimeng, Kam, Antony
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cysteine-Rich Peptides; Cell Penetration; Microproteins; Metal-Binding Peptides; Coffee Waste Product; Chemical Synthesis; Hevein-Like Peptide; Non-Chitin Binding Hevein; Ginsentide
• Online Access: https://hdl.handle.net/10356/170613
• Institution: Nanyang Technological University

Coffee processing generates a huge amount of waste that contains many natural products. Here, we report the discovery of a panel of novel cell-penetrating and metal ion-binding microproteins designated coffeetide cC1a–c and cL1–6 from the husk of two popular coffee plants, Coffea canephora and Coffe...