MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation

• Main Authors: Tomaz, Lucian B., Liu, Bernard A., Meroshini, M., Ong, Sheena L. M., Tan, Ee Kim, Tolwinski, Nicholas S., Williams, Christopher S., Gingras, Anne-Claude, Leushacke, Marc, Dunn, N. Ray
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; immunohistochemistry; Mass spectrometry
• Online Access: https://hdl.handle.net/10356/170810
• Institution: Nanyang Technological University

The gene mutated in colorectal cancer (MCC) encodes a coiled-coil protein implicated, as its name suggests, in the pathogenesis of hereditary human colon cancer. To date, however, the contributions of MCC to intestinal homeostasis and disease remain unclear. Here, we examine the subcellular localiza...