Cholesterol-stabilized membrane-active nanopores with anticancer activities

• Main Authors: Shen, Jie, Gu, Yongting, Ke, Lingjie, Zhang, Qiuping, Cao, Yin, Lin, Yuchao, Wu, Zhen, Wu, Caisheng, Mu, Yuguang, Wu, Yun-Long, Ren, Changliang, Zeng, Huaqiang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science; Membranes; Nanopores
• Online Access: https://hdl.handle.net/10356/170821
• Institution: Nanyang Technological University

Cholesterol-enhanced pore formation is one evolutionary means cholesterol-free bacterial cells utilize to specifically target cholesterol-rich eukaryotic cells, thus escaping the toxicity these membrane-lytic pores might have brought onto themselves. Here, we present a class of artificial cholestero...