Discrete LAT condensates encode antigen information from single pMHC:TCR binding events

LAT assembly into a two-dimensional protein condensate is a prominent feature of antigen discrimination by T cells. Here, we use single-molecule imaging techniques to resolve the spatial position and temporal duration of each pMHC:TCR molecular binding event while simultaneously monitoring LAT conde...

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Bibliographic Details
Main Authors: McAffee, Darren B., O'Dair, Mark K., Lin, Jenny J., Low-Nam, Shalini T., Wilhelm, Kiera B., Kim, Sungi, Morita, Shumpei, Groves, Jay T.
Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/170829
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Institution: Nanyang Technological University
Language: English