Engineering tumoral vascular leakiness with gold nanoparticles

• Main Authors: Setyawati, Magdiel Inggrid, Wang, Qin, Ni, Nengyi, Tee, Jie Kai, Ariga, Katsuhiko, Ke, Pu Chun, Ho, Han Kiat, Wang, Yucai, Leong, David Tai
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Materials; Engineering::Bioengineering; Tumor Vascularization; Micrometastasis
• Online Access: https://hdl.handle.net/10356/170939
• Institution: Nanyang Technological University

Delivering cancer therapeutics to tumors necessitates their escape from the surrounding blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer therapeutically competent leakage of therapeutics from tumor vasculature with gold nanoparticles capable of inducing endoth...