Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition

• Main Authors: Wong, Jun Jie, Ho, Foo Kiong, Choo, Pei Yi, Chong, Kelvin Kian Long, Ho, Benjamin Chee Meng, Neelakandan, Ramesh, Keogh, Damien, Barkham, Timothy, Chen, John, Liu, Chuan Fa, Kline, Kimberly A.
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Complete Genome Sequence; Virulence
• Online Access: https://hdl.handle.net/10356/170990
• Institution: Nanyang Technological University

Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing. Escherichia coli and Staphylococcus aureus are among the most frequently cultured pathogens from wound infections. However, little is known about...