A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

• Main Authors: Tay, Apple Hui Min, Prieto-Díaz, Rubén, Neo, Shiyong, Tong, Le, Chen, Xinsong, Carannante, Valentina, Önfelt, Björn, Hartman, Johan, Haglund, Felix, Majellaro, Maria, Azuaje, Jhonny, Garcia-Mera, Xerardo, Brea, Jose M., Loza, Maria I., Jespers, Willem, Gutierrez-de-Teran, Hugo, Sotelo, Eddy, Lundqvist, Andreas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Adenosine; Immunotherapy
• Online Access: https://hdl.handle.net/10356/171035
• Institution: Nanyang Technological University

Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A2ARs. While blockade of the A2AARs subtype effectively rescues lymphocyte activity, with four A2AAR antagonists currently in anticancer clini...