Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression

• Main Authors: Liu, Xinyu, Jiang, Liqin, Ke, Mengyuan, Sigal, Ian A., Chua, Jacqueline, Hoang, Quan V., Chia, Audrey W. I., Najjar, Raymond P., Tan, Bingyao, Cheong, Jocelyn, Bellemo, Valentina, Chong, Rachel S., Girard, Michaël J. A., Ang, Marcus, Liu, Mengyang, Garhöfer, Gerhard, Barathi, Veluchamy A., Saw, Seang-Mei, Villiger, Martin, Schmetterer, Leopold
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Engineering::Bioengineering; Myopia Progression; Polarization Sensitive
• Online Access: https://hdl.handle.net/10356/171053
• Institution: Nanyang Technological University

In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the techni...