Automated pipetting robot for proxy high-throughput viscometry of Newtonian fluids

In this work, we develop a high-throughput viscometer for Newtonian fluids with viscosities between 1500 and 12 000 cP. The viscometer is developed based on an automated pipetting robot Opentrons (OT-2), with a commercial wide bore tip. The measurement protocol exploits the known characteristics of...

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Bibliographic Details
Main Authors: Soh, Beatrice W., Chitre, Aniket, Lee, Wen Yang, Bash, Daniil, Kumar, Jatin N., Hippalgaonkar, Kedar
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/171075
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Institution: Nanyang Technological University
Language: English
Description
Summary:In this work, we develop a high-throughput viscometer for Newtonian fluids with viscosities between 1500 and 12 000 cP. The viscometer is developed based on an automated pipetting robot Opentrons (OT-2), with a commercial wide bore tip. The measurement protocol exploits the known characteristics of air-displacement pipettes in dispensing and gravimetrically measuring fluids of different viscosities. Specifically, by measuring the actual dispense flow rate of fluids with varying viscosities under fixed dispense conditions, we construct a calibration curve and propose a scaling analysis based on flow through an idealized pipette tip geometry. Our model can predict the viscosity of Newtonian fluids with an error of 6.5%. We also showcase the flexibility of our platform by integrating a custom-design tip for a different viscosity range.