Membrane curvature governs the distribution of Piezo1 in live cells

• Main Authors: Yang, Shilong, Miao, Xinwen, Arnold, Steven, Li, Boxuan, Ly, Alan T., Wang, Huan, Wang, Matthew, Guo, Xiangfu, Pathak, Medha M., Zhao, Wenting, Cox, Charles D., Shi, Zheng
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Mammals; Cell Membrane
• Online Access: https://hdl.handle.net/10356/171168
• Institution: Nanyang Technological University

Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian cells. The distribution of Piezo1 within a cell is essential for various biological processes including cytokinesis, cell migration, and wound healing. However, the underlying principles that guide the subcellular...