Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

• Main Authors: Bláha, Jan, Skálová, Tereza, Kalousková, Barbora, Skořepa, Ondřej, Cmunt, Denis, Grobárová, Valéria, Pazicky, Samuel, Poláchová, Edita, Abreu, Celeste, Stránský, Jan, Kovaľ, Tomáš, Dušková, Jarmila, Zhao, Yuguang, Harlos, Karl, Hašek, Jindřich, Dohnálek, Jan, Vaněk, Ondřej
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Membrane Antigen; Cell Surface Receptor
• Online Access: https://hdl.handle.net/10356/171170
• Institution: Nanyang Technological University

Signaling by the human C-type lectin-like receptor, natural killer (NK) cell inhibitory receptor NKR-P1, has a critical role in many immune-related diseases and cancer. C-type lectin-like receptors have weak affinities to their ligands; therefore, setting up a comprehensive model of NKR-P1-LLT1 inte...