Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells

• Main Authors: He, Qianqian, Sze, Siu Kwan, Ng, Kai Soon, Koh, Cheng-Gee
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Focal Adhesion; Paxillin
• Online Access: https://hdl.handle.net/10356/171191
• Institution: Nanyang Technological University

Self-renewal and differentiation of mouse embryonic stem cells (mESCs) are greatly affected by the extracellular matrix (ECM) environment; the composition and stiffness of which are sensed by the cells via integrin-associated focal adhesions (FAs) which link the cells to the ECM. Although FAs have b...