Transcriptomics indicate nuclear division and cell adhesion not recapitulated in MCF7 and MCF10A compared to luminal a breast tumours

• Main Authors: Goh, Jeremy Joon Ho, Goh, Corinna Jie Hui, Lim, Qian Wei, Zhang, Songjing, Koh, Cheng-Gee, Chiam, Keng-Hwee
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cell Adhesion; Cell Nucleus Division
• Online Access: https://hdl.handle.net/10356/171206
• Institution: Nanyang Technological University

Breast cancer (BC) cell lines are useful experimental models to understand cancer biology. Yet, their relevance to modelling cancer remains unclear. To better understand the tumour-modelling efficacy of cell lines, we performed RNA-seq analyses on a combined dataset of 2D and 3D cultures of tumourig...