Gasdermin D-deficient mice are hypersensitive to acute kidney injury

• Main Authors: Tonnus, Wulf, Maremonti, Francesca, Belavgeni, Alexia, Latk, Markus, Kusunoki, Yoshihiro, Brucker, Anne, Mässenhausen, Anne von, Meyer, Claudia, Locke, Sophie, Gembardt, Florian, Beer, Kristina, Hoppenz, Paul, Becker, Jan U., Hugo, Christian, Anders, Hans-Joachim, Bornstein, Stefan R., Shao, Feng, Linkermann, Andreas
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Acute Kidney Tubule Necrosis; Renal Ischemia Reperfusion Injury
• Online Access: https://hdl.handle.net/10356/171278
• Institution: Nanyang Technological University

Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expression in the...