Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus

• Main Authors: Chaudhary, Deepika, Singh, Avantika, Marzuki, Mardiana, Ghosh, Abhirupa, Kidwai, Saqib, Gosain, Tannu Priya, Chawla, Kiran, Gupta, Sonu Kumar, Agarwal, Nisheeth, Saha, Sudipto, Kumar, Yashwant, Thakur, Krishan Gopal, Singhal, Amit, Singh, Ramandeep
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Biological sciences; Homoserine; Molecular Docking Simulation
• 在線閱讀: https://hdl.handle.net/10356/171285
• 機構: Nanyang Technological University

There is an urgent need to validate new drug targets and identify small molecules that possess activity against both drug-resistant and drug-sensitive bacteria. The enzymes belonging to amino acid biosynthesis have been shown to be essential for growth in vitro, in vivo and have not been exploited m...