Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources

• Main Authors: Regha, Kakkad, Bhargava, Mayuri, Al-Mubaarak, Abdurrahmaan, Chai, Chou, Parikh, Bhav Harshad, Liu, Zengping, Wong, Claudine See Wei, Hunziker, Walter, Lim, Kah Leong, Su, Xinyi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cell Differentiation; Retinal Pigment Epithelium
• Online Access: https://hdl.handle.net/10356/171295
• Institution: Nanyang Technological University

Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-related macular degeneration. A promising therapeutic option is RPE cell transplantation. Development of clinical grade stem-cell derived RPE requires efficient in vitro differentiation and purification methods. E...