Molecular docking reveals critical residues in Candida albicans Cyr1 for peptidoglycan recognition and hyphal growth

• المؤلفون الرئيسيون: Ng, Allan Wee Ren, Li, Lanxin, Ng, Evan Wei Long, Li, Chenyu, Qiao, Yuan
• مؤلفون آخرون: School of Chemistry, Chemical Engineering and Biotechnology
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Chemistry; Ligand-receptor Recognition; Peptidoglycan
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171430
• المؤسسة: Nanyang Technological University

The key virulent characteristic of Candida albicans, the major fungal pathogen in humans, lies in its ability to switch between the benign yeast state and the invasive hyphal form upon exposure to specific stimuli. Among the numerous hyphal-inducing signals, bacterial peptidoglycan fragments (PGNs)...