Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations

• المؤلفون الرئيسيون: Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Mathematics; Protein; Insights
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171438
• المؤسسة: Nanyang Technological University

The Coronavirus disease 2019 (COVID-19) has affected people's lives and the development of the global economy. Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. In this study, we prov...