Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

• Main Authors: Nutma, Erik, Fancy, Nurun, Weinert, Maria, Tsartsalis, Stergios, Marzin, Manuel C., Muirhead, Robert C. J., Falk, Irene, Breur, Marjolein, de Bruin, Joy, Hollaus, David, Pieterman, Robin, Anink, Jasper, Story, David, Chandran, Siddharthan, Tang, Jiabin, Trolese, Maria C., Saito, Takashi, Saido, Takaomi C., Wiltshire, Katharine H., Beltran-Lobo, Paula, Phillips, Alexandra, Antel, Jack, Healy, Luke, Dorion, Marie-France, Galloway, Dylan A., Benoit, Rochelle Y., Amossé, Quentin, Ceyzériat, Kelly, Badina, Aurélien M., Kövari, Enikö, Bendotti, Caterina, Aronica, Eleonora, Radulescu, Carola I., Wong, Jia Hui, Barron, Anna M., Smith, Amy M., Barnes, Samuel J., Hampton, David W., van der Valk, Paul, Jacobson, Steven, Howell, Owain W., Baker, David, Kipp, Markus, Kaddatz, Hannes, Tournier, Benjamin B., Millet, Philippe, Matthews, Paul M., Moore, Craig S., Amor, Sandra, Owen, David R.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Experimental Autoimmune Encephalomyelitis; Alzheimers-disease
• Online Access: https://hdl.handle.net/10356/171517
• Institution: Nanyang Technological University

Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative interpretation remains uncertain. We show that TSPO...