Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

• Main Authors: Yang, Jing, Yang, Na, Zhao, Huifang, Qiao, Yan, Li, Yanqiu, Wang, Chunfang, Lim, Kah-Leong, Zhang, Chengwu, Yang, Wulin, Lu, Li
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Lipid Metabolism; Subventricular Zone
• Online Access: https://hdl.handle.net/10356/171527
• Institution: Nanyang Technological University

Background: Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced neuropathy is not well elucidated, and the possible restorative strategy needs to...