Altered gut microbiota-host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern

• Main Authors: Du, Liqing, Zhang, Zhaozhou, Zhai, Lixiang, Xu, Shujun, Yang, Wei, Huang, Chunhua, Lin, Chengyuan, Zhong, Linda Lidan, Bian, Zhaoxiang, Zhao, Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Traditional Chinese Medicine; Gut Microbiota
• Online Access: https://hdl.handle.net/10356/171549
• Institution: Nanyang Technological University

Background: Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional Chinese Medicine (TCM), instructed by pattern differentiation, is effective in treating IBS-D, in which liver depression...