Highly sensitive and label-free detection of biotin using a liquid crystal-based optofluidic biosensor

• Main Authors: Wang, Haonan, Xu, Tianhua, Wang, Ziyihui, Liu, Yize, Chen, Huaixu, Jiang, Junfeng, Liu, Tiegen
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Electrical and electronic engineering; Coenzymes; Whispering Gallery Modes
• Online Access: https://hdl.handle.net/10356/171551
• Institution: Nanyang Technological University

A liquid crystal (LC)-based optofluidic whispering gallery mode (WGM) resonator has been applied as a biosensor to detect biotin. Immobilized streptavidin (SA) act as protein molecules and specifically bind to biotin through strong non-covalent interaction, which can interfere with the orientation o...